Inflammation on the crossword of Parkinson’s disease and COVID-19

Worldwide pandemic of COVID-19 has resulted in various physiological manifestations mainly affecting the respiratory system and also nervous system. Inflammation, a hallmark symptom diseases links both neurodegenerative disorders. infection immune responses like cytokine chemokine production, even storms (in severe cases), which lead to inflammation. Parkinson’s Disease (PD), characterised by motor difficulties is due α-synuclein aggregates disease known have dual instigations. In one way central inflammation caused tissue injury, glial cell dysfunction proinflammatory molecule resulting Blood Brain Barrier leakage another peripheral occurs altered gut microbiome after pathogen attack, producing inflammatory mediators. Inflammation being potential threat for onset progression PD major concern this article. Immediate effect might be ailment hypoxia contribute but long-lasting effects are uncertain increase future. Anti-inflammatory therapeutic interventions already shown varied results infections stages its impact on yet studied. Here, we elucidated role pathophysiology developing new approach targeting cascade.